Introduction Of Secretory Diarrhea

Secretory diarrhea means that there is an increase in the active secretion, or there is an inhibition of absorption. The most common cause of this type of diarrhea is a cholera toxin and E.coli those stimulate the secretion of anions, especially chloride ions .Bacterial and viral infections usually included in the etiology of diarrhea  and these pathogens are present in wide diversity which complicates the process of  accurate surveillance and diagnosis, especially in developing countries with little or no access to modern laboratory procedures. The specific disease burden attributable to a particular infectious agent is particularly complex, given the multiplicity of these agents and their serotypes, and its accurate documentation depends largely on laboratory facilities. While, in the long term, access to clean water, better hygiene, adequate nutrition, and improvement of sanitary measures would certainly have the greatest impact on diarrhea diseases, Some other varieties of bacterial pathogens such as Staphylococcus aureus, Clostridium perfringens, Clostridium difficile or Klebsiella spp, as well as by various protozoa including Giardia, Cyclospora and Cryptosporidium spp (e.g. Giardia lambia, Cryptosporidium parvum) and Entamoeba histolytica are also included in etiology of diarrhea diseases. The leading cause of diarrhea disease in young children throughout the world is rotavirus.

Significance of the results

A significant difference was identified, concluding that frequency of diarrhea and associated symptoms were significantly reduced when treated with Dirasif. The data offered support to the experimental hypothesis and therefore null hypothesis was rejected.

Epidemiology

Diarrhea diseases are one of the leading causes of childhood morbidity and mortality in developing countries. An estimated 1,000 million episodes occur each year in children under 5 years of age. Diarrhea causes an estimated 5 million deaths in children fewer than 5 years of age per year. About 80% of these deaths occur in children in the first 2 years of life. Approximately one third of deaths among children fewer than five are caused by diarrhea . In the year 2000, diarrhea diseases claimed an estimated 1.4 to 2.5 million lives; they are among the leading causes of death in children in developing countries. Both the incidence and the risk of mortality from diarrhea diseases are greatest among children younger than 1 year of age, and thereafter rates decline incrementally. Other direct consequences of diarrhea in children include malnutrition, diminished growth, and impaired cognitive development in resource-limited countries.